Chinese Factory Supply Calcium folinatc, Factory Sells 6035-45-6 In Bulk Supply
- Molecular Formula:C20H31CaN7O12
- Molecular Weight:511.507
- Appearance/Colour:yellowish-white to yellow powder
- Melting Point:240-250oC
- PSA：427.76000
- LogP:-0.54600
Calcium folinatc(Cas 6035-45-6) Usage
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Chemical Properties
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yellowish-white to yellow powder
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Uses
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An intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers.
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Brand name
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Wellcovorin (GlaxoSmithKline).
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Biological Activity
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human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (mtx)-induced growth suppression. over a 72h continuous exposure leucovorin provided better protection to the cell lines laz-007 and raji than to the cell line
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InChI:InChI=1/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/q;+2;;;;;/p-2/t12?,13-;;;;;;/m0....../s1
6035-45-6 Relevant articles
Process for the preparation and separation of diastereomeric salts of folinic acid
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, (2008/06/13)
A process for the preparation, separatio...
Process for separating folinic acid
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, (2008/06/13)
Preparing (6S)-folinic acid and its salt...
6035-45-6 Process route
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- 6035-45-6
Leucovorin Calcium
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- 6035-45-6
Leucovorin Calcium
Conditions
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Yield |
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With hydrogenchloride; In water; at 6 - 10 ℃; for 4h; pH=2.8 - 3.2;
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99.4 % ee |
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With acetic acid; In water; at 2 - 12 ℃; pH=2.5 - 3.5;
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6035-45-6 Downstream products
