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6035-45-6

  • Product NameCalcium folinatc
  • Molecular FormulaC20H31CaN7O12
  • Molecular Weight511.507
  • Purity99%
  • Appearanceyellowish-white to yellow powder
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Product Details

Quick Details

  • CasNo: 6035-45-6
  • Molecular Formula: C20H31CaN7O12
  • Appearance: yellowish-white to yellow powder
  • Purity: 99%

Chinese Factory Supply Calcium folinatc, Factory Sells 6035-45-6 In Bulk Supply

  • Molecular Formula:C20H31CaN7O12
  • Molecular Weight:511.507
  • Appearance/Colour:yellowish-white to yellow powder 
  • Melting Point:240-250oC 
  • PSA:427.76000 
  • LogP:-0.54600 

Calcium folinatc(Cas 6035-45-6) Usage

Chemical Properties

yellowish-white to yellow powder

Uses

An intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers.

Brand name

Wellcovorin (GlaxoSmithKline).

Biological Activity

human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (mtx)-induced growth suppression. over a 72h continuous exposure leucovorin provided better protection to the cell lines laz-007 and raji than to the cell line

InChI:InChI=1/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/q;+2;;;;;/p-2/t12?,13-;;;;;;/m0....../s1

6035-45-6 Relevant articles

Process for the preparation and separation of diastereomeric salts of folinic acid

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, (2008/06/13)

A process for the preparation, separatio...

Process for separating folinic acid

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, (2008/06/13)

Preparing (6S)-folinic acid and its salt...

6035-45-6 Process route

Leucovorin Calcium
6035-45-6

Leucovorin Calcium

Conditions
Conditions Yield
 
 
 
 
Leucovorin Calcium
6035-45-6

Leucovorin Calcium

folinic acid
58-05-9

folinic acid

Conditions
Conditions Yield
With hydrogenchloride; In water; at 6 - 10 ℃; for 4h; pH=2.8 - 3.2;
99.4 % ee
With acetic acid; In water; at 2 - 12 ℃; pH=2.5 - 3.5;
 

6035-45-6 Downstream products

  • 58-05-9
    58-05-9

    folinic acid

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