Export Buy High Quality 4-HYDROXYTHIOBENZAMIDE 25984-63-8 On Stock
- Molecular Formula:C7H7NOS
- Molecular Weight:153.205
- Appearance/Colour:Grey white powder
- Vapor Pressure:0mmHg at 25°C
- Melting Point:181-185℃
- Refractive Index:1.702
- Boiling Point:320.394 °C at 760 mmHg
- PKA:9.24±0.26(Predicted)
- Flash Point:147.57 °C
- PSA：78.34000
- Density:1.339 g/cm3
- LogP:1.72670
4-Hydroxythiobenzamide(Cas 25984-63-8) Usage
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Uses
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4-Hydroxythiobenzamide is used in the synthesis of PPARα agonists used in increasing HDLc levels. Also used in the synthesis of potent CDK5 inhibitors in the treatment of Alzheimer’s disease. |
InChI:InChI=1/C7H7NOS/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
25984-63-8 Relevant articles
Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action
Yahia, Eman,Mohammad, Haroon,Abdelghany, Tamer M.,Fayed, Eman,Seleem, Mohamed N.,Mayhoub, Abdelrahman S.
, p. 604 - 613 (2017)
Antibacterial resistance is a pressing g...
Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents
Chen, Jianjun,Chen, Jingxuan,Huang, Junli,Li, Ling,Liu, Jin,Peng, Xiaopeng,Ren, Yichang,Sun, Zhiqiang
, p. 8447 - 8473 (2021/06/28)
Novel dual HDAC3/tubulin inhibitors were...
New preparation method of febuxostat intermediate
-
Paragraph 0059-0061, (2020/03/06)
The invention relates to a new preparati...
Synthesis, molecular docking, DFT study of novel N-benzyl-2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxamide derivatives and their antibacterial activity
Sam Daniel Prabu,Lakshmanan, Sivalingam,Thirumurugan,Ramalakshmi,Arul Antony
, p. 619 - 626 (2020/02/06)
A series of febuxostat based new chemica...
SSAO INHIBITOR
-
Paragraph 0435; 0436; 0437; 0589; 0590; 0591, (2020/04/02)
The present invention provides an SSAO i...
25984-63-8 Process route
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619-57-8
p-hydroxybenzamide
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25984-63-8
4-hydroxythiobenzamide
Conditions
| Conditions |
Yield |
|
With
Lawessons reagent;
In
tetrahydrofuran;
at 20 ℃;
for 6h;
|
87%
|
|
With
Lawessons reagent;
In
2-methyltetrahydrofuran;
at 0 - 30 ℃;
for 12h;
|
|
|
With
Lawessons reagent;
|
|
-
-
25984-63-8
4-hydroxythiobenzamide
Conditions
| Conditions |
Yield |
|
4-cyanophenol;
With
sodium hydrogensulfide;
In
water;
at 20 ℃;
for 0.5h;
With
hydrogen sulfide;
at 70 ℃;
for 5.91667 - 6h;
under 2068.65 - 2896.11 Torr;
|
97.57%
|
|
With
sodium monohydrogen sulfide x-hydrate; ammonium chloride;
In
water; N,N-dimethyl-formamide;
at 40 ℃;
for 22h;
Product distribution / selectivity;
|
94%
|
|
With
sodium hydrogen sulfide; triethylamine hydrochloride; triethylamine;
In
ethanol;
at 5 - 50 ℃;
for 12h;
Reagent/catalyst;
Solvent;
Temperature;
|
92%
|
|
With
sodium monohydrogen sulfide x-hydrate; ammonium chloride;
In
water; N,N-dimethyl-formamide;
at 40 ℃;
for 22h;
|
90%
|
|
With
O,O-Diethyl hydrogen phosphorodithioate;
In
water;
at 50 ℃;
for 3h;
|
87.5%
|
|
With
pyridine; ammonium sulfide;
In
water;
at 20 ℃;
|
83%
|
|
With
O,S-diethyl-dithiophosphoric acid;
In
water;
at 80 ℃;
for 1h;
|
78%
|
|
With
tetraphosphorus decasulfide;
In
ethanol;
at 70 ℃;
for 10h;
|
78%
|
|
With
tetraphosphorus decasulfide;
In
ethanol;
at 70 ℃;
for 12h;
|
70%
|
|
With
hydrogen sulfide; ammonium chloride;
In
N,N-dimethyl-formamide;
at 50 - 95 ℃;
under 1520.1 - 3040.2 Torr;
Autoclave;
Inert atmosphere;
|
68.4%
|
|
With
hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate;
In
ethyl acetate;
at 20 ℃;
|
39%
|
|
With
pyridine; hydrogen sulfide; triethylamine;
for 24h;
Ambient temperature;
|
38%
|
|
With
hydrogen sulfide; triethylamine;
In
pyridine;
|
|
|
With
diammonium sulfide;
In
methanol;
at 130 ℃;
for 0.5h;
microwave irradiation;
|
40 % Spectr.
|
|
With
hydrogenchloride; NaSH;
In
water;
|
62.74 g (97.57%)
|
|
With
tetraphosphorus decasulfide;
In
ethanol;
at 70 ℃;
for 12h;
|
|
|
With
sodium hydrogensulfide; magnesium chloride monohydrate;
at 20 ℃;
for 3h;
|
|
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-
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-
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2-(4-hydroxy-phenyl)-thiazole-4-carboxylic acid hydrazide
